Drug interactions with smoking
Numerous drug interactions exist with smoking. Therefore, smokers taking a medication of higher dosage than nonsmokers. Polycyclic aromatic hydrocarbons of tobacco have been associated with the induction of CYP enzymes. By using CYP1A1, CYP1A2, CYP2E1 and UGT enzymes, drugs which are metabolized might be affected by tobacco smoking and the smokers who are taking the medications metabolized by those enzymes, may need higher dosage due to lowered plasma concentrations through enhanced induction by PAHs of tobacco smoke. The pharmacists are to be aware of medications affected by tobacco smoking to prevent the toxicity-associated complications during smoking cessation.
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